quantiferon mitogen value normal range

[4][5] However, one of the five sites involved in the CDC study reported less agreement. wallpaper for laptop aesthetic; . However, as with a TST, there is a possibility that live vaccines might affect the test results of the QuantiFERON TB Gold test. Woo KS, Choi JL, Kim BR, Kim JE, Kim BG, Lee H, et al. The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome. . significantly above the Nil IFN- IU/ml value. PWM and PHA were heat stable, while Con A was heat sensitive. Third, among confirmed TB patients, a weak mitogen response was associated with false negative QFT results. The result of the test is a numeric value that relates to a continuous numeric scale. When considering both clinical and biological variables (model 3), multivariable analysis revealed that lower serum albumin, hemoglobin and lymphocytes, but higher neutrophil counts were independently associated with both a negative and weak mitogen responses (vs. normal). I was so amazed with their customer service. - by IGRAs cannot distinguish between latent infection and active tuberculosis (TB) disease, and should not be used as a sole method for diagnosis of active TB, which is a microbiological diagnosis. (2020) 18:457. quantiferon mitogen value normal range Learn how we helped our several clients grow in online business.It will give you an idea of our capabilities. The mitogen tube must have a gamma interferon value 0.5 IU/mL higher than the value of the Nil tube, for the positive control and the test to be valid. Quantiferon Mitogen minus NIL: result > 10.00 IU/mL. Indeterminate due to Low Mitogen Value: Indeterminate due to a low IFN-gamma level in the mitogen (positive control) tube. Detection of interferon-y by enzyme-linked immunosorbent assay (elisa) is used to identify in vitro responses to these peptide antigens that are associated with mycobacterium tuberculosis infection. In our study, the statistically derived cut-off value of QFT-Plus used for the accuracy analysis was 0.168 IU/mL, which is much lower than the currently recommended value of 0.35 IU/mL; thus, the . Clinical evaluation and additional tests (such as a chest radiograph, sputum smear, and culture) are needed to differentiate between a diagnosis of latent TB or active TB. Szenzitizlt egynek friss heparinizlt teljes vr mintjban tuberkulzis antignek hatsra T sejtekbl gamma interferon szabadul fel. (2017) 43:133-41. doi: 10.1080/1040841X.2016.1185603, 18. If performed in such a context, clinicians must interpret QFT with caution, especially if mitogen response if weak (IFN- = 0.52 IU/ml), whatever the official interpretation. Please enable it to take advantage of the complete set of features! Infections are frequent in hospitalized patients, but our results suggest QFT should not be performed until after recovery. Unable to load your collection due to an error, Unable to load your delegates due to an error, Inverse correlation between INF- mitogen response and C-reactive protein levels in hospitalized patients. Performance. A high altitude kit is also available for . How it could be impacted and associated with outcomes is poorly known. %PDF-1.5 % The package insert also advises that the kit provides three collection tubes which have had antigens dried onto their walls and that these tubes must be transferred to an incubator within 16 hours of blood collection. (2010) 35:1179-82. PLoS One. See this image and copyright information in PMC. Range of Values: 1581: 1581. (2021) 22:2-6. J Infect Dis. [11] Research at Stanford University and the Veterans Administration has reported the use of a retesting (or borderline) zone below 1.1 IU/ml mitigates 76% of the false-positives, or reversions. Our case-control study involving 872 hospitalized patients who underwent QFT testing yielded four main results. NIL 0.07 IU/mL KS MITOGEN-NIL >10.00 IU/mL KS TB-NIL 0.00 IU/mL KS The Nil tube value is used to determine if the patient has a preexisting immune response which could cause a Outside the scope of TB, the weak mitogen response was independently associated with ongoing infections and could be associated with a worse prognosis. QFT was less frequently positive if mitogen response was weak (25% of cases) compared to normal (80% of cases). The mitogen tube must demonstrate an interferon- value of 0.5 IU/ml higher than the value of the NIL tube. The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author. Emerg Med J. We recognize that technique may not be the only factor and we accept that mitogen values are currently not in a range that customers have previously observed. Before Comparison of two commercial interferon-gamma assays for diagnosing Mycobacterium tuberculosis infection. what is the smallest header in html by default : Clin Chim Acta 2014;430:79-83. Comparisons were made between the three groups using KruskalWallis tests or ANOVA when appropriate for continuous variables, and the Chi-square test for qualitative variables. Test Name Result Flag Reference Range Lab QUANTIFERON(R)-TB GOLD QUANTIFERON(R)-TB GOLD NEGATIVE NEGATIVE KS Negative test result. J Clin Microbiol. An ongoing infection was independently associated with both a negative (RR = 4.34; 95% CI = 2.946.41) and a weak mitogen response (RR = 2.44; 95% CI = 1.663.58). carnival alaska cruise 2022; update data without refresh page in angular 11. supersport premier league channel number on gotv. Indeterminate results are obtained in 8 to 29% of patients (35). After incubation of the blood with antigens for 16 to 24 hours, the amount of interferon-gamma (IFN-gamma) is measured. None. May 10, 2022 Septic shock as sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure 65 mm Hg and had a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation (19). Objectives With the rapid expansion of the IGRA evidence-base in . QuantiFERON-TB Gold In-Tube, QIAGEN (QFT-Gold) QuantiFERON-TB Gold Plus, QIAGEN (QFT-Plus) T-SPOT.TB, Oxford Immunotec The last order date for the QuantiFERON-TB Gold In-Tube assay will be June 29, 2018 and will be discontinued and no longer be available for purchase as of June 30, 2018. Brands X, Haak BW, Klarenbeek AM, Otto NA, Faber DR, Lutter R, et al. You have taken the Quantiferon Gold TB test, and based on the values, TB can be ruled out. It is generally recommended to results where Nil > 8.0 IU/ml (high background) consider . Tuberculin skin testing (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) and includes measurement of the delayed type hypersensitivity response 4872 hours after intradermal injection of PPD. Second, patients with a weak mitogen response and negative mitogen response had several similarities. Give us a 5-Star Review on Google! (2020) 11:1364. doi: 10.3389/fimmu.2020.01364. what is a normal mitogen level; change page title html. QuantiFERON-TB Gold Plus, 1 Tube - This test is a blood-based interferon-gamma release assay (IGRA) used as an aid in the diagnosis of Mycobacterium tuberculosis infection. Figure 1. official website and that any information you provide is encrypted 0000004397 00000 n Clinical outcomes of 872 hospitalized patients according to the mitogen response of QFT (negative, weak or normal). Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. . Suite 155Las Vegas, results cannot be interpreted as a result of low mitogen response or high background response. The 2010 guidelines establish a new benchmark because they recommend IGRAs as the preferred TB testing method in many patients, including those who are BCG vaccinated or are unlikely to return for TST reading. (2018) 31:e2118. Low values can occur due to sample handling errors that adversely impact lymphocyte activity/viability, low lymphocyte counts, and other factors that decrease cell mediated immune responses. Among the 2,023 patients (82%) with a normal mitogen response (IFN- > 2 IU/ml), 436 were included as controls. Applies only to results expressed in units of measure originally reported by the performing laboratory. Powell RD 3rd, Whitworth WC, Bernardo J, Moonan PK, Mazurek GH. The tubes are shaken to mix antigen with the whole blood and incubated at 37 C + 1 C for 16 to 24 hours. previously reported that a lower mitogen response was associated with worse 1-year survival in TB patients (27). 0000002584 00000 n xref Furthermore, our data for patients with microbiologically confirmed TB are illustrative. Decreasing mitogen response (normal, weak and negative, respectively) was associated with increasing length of hospital stay [median (interquartile range) 5 (313), 11 (521) and 15 (1030) days; p < 0.001] and increasing hospital mortality (3, 7, and 15%; p < 0.001). Value. Results: A total of 872 patients were included. PERFECT!! Bethesda, MD 20894, Web Policies In areas of low risk and low prevalence, the positive predictive value of any test is diminished. The normal, weak and negative mitogen response (respectively) was associated with decreasing hemoglobin, albumin and lymphocyte counts, but increasing neutrophil count and C-reactive protein levels (Table 1). quantiferon mitogen value normal range. Among tuberculosis patients . In this case, generally, the test must be retaken with a fresh blood sample. During the study period, 8,260 QFT were performed, including 2,459 in adult patients hospitalized for at least 48 h (Supplementary Figure 1). 0000024723 00000 n and transmitted securely. It decreased again in the U.S. in 1993 but is still a concern as tuberculosis cases can re-emerge. More automation will be needed to accurately measure the QFT response. A p-value < 0.05 was considered statistically significant. [12], To its disadvantage, QFT can yield false positive results with Mycobacterium szulgai, Mycobacterium kansasii, and Mycobacterium marinum.[14]. Results are expressed as relative risks (RR) and 95% confidence intervals (CI). -. Correlation between INF- mitogen response of QFT and C-reactive protein levels was assessed in hospitalized patients included in the study and with available C-reactive protein data (, Clinical outcomes of 872 hospitalized patients according to the mitogen response of QFT (negative, weak or normal). 0000001385 00000 n If the level of blood in any tube . 0000015986 00000 n Fourth, the mitogen response was associated with hospital length of stay and in-hospital mortality. Decreasing mitogen response (normal, weak and negative, respectively) was associated with increasing length of hospital stay [median (interquartile range) 5 (3-13), 11 (5-21) and 15 (10-30) days; p < 0.001] and increasing hospital mortality (3, 7, and 15%; p < 0.001). In addition, this was a single center study when considering the laboratory which performed QFT, and the results may not be reproducible in other settings. The use of QuantiFERON-TB Gold In-Tube (QFT, Qiagen) testing, which uses IGRA, is increasingly used to screen LTI. 0000012959 00000 n In addition, male sex, diabetes, and an infection within 3 months before QFT were independently associated with a negative mitogen response, but not with a weak mitogen response, as compared with a normal response (Model 1, Table 2). The median values of three mitogens were in the following order: PWMCon A positive control>>PHA-P>>negative control. (1999) 180:2069-73. doi: 10.1086/315114. Eur Respir J. Careers - The mitogen tube must demonstrate an interferon- value of equal to or greater than 0.5 IU/ml higher than the value of the NIL tube. In addition, mitogen response was inversely correlated with C-reactive protein concentrations (Figure 1). Last edited on 20 February 2023, at 09:25, Learn how and when to remove this template message, bacille Calmette-Gurin (BCG) vaccination, public health laboratories, hospitals, and commercial laboratories, "WHO IGRA TB TESTS Policy Statement 2011", "Guidelines for Using the QuantiFERON-TB Test for Diagnosing Latent, "Comparison of a Whole-Blood Interferon Assay With Tuberculin Skin Testing for Detecting Latent Mycobacterium tuberculosis Infection", "Evaluation of the Tuberculin Gamma Interferon Assay: Potential To Replace the Mantoux Skin Test", "Evaluation of a WholeBlood Interferon Release Assay for the Detection of Mycobacterium tuberculosis Infection in 2 Study Populations", "Comparison of Mantoux and QuantiFERON TB Gold Tests for Diagnosis of Latent Tuberculosis Infection in Army Personnel", "Repeat IGRA Testing in Canadian Health Workers: Conversions or Unexplained Variability? Latent TB can become active TB after several weeks, or even years, after infection. 20. As noted above, prior BCG vaccination can produce false positive TST results. Such observations suggest that ongoing infection could be a frequent cause of negative mitogen response. The mitogen threshold of 2 IU/mL was arbitrary defined to obtain balanced groups between negative and weak mitogen response groups. Confirm volume in all 4 tubes (Grey top NIL tube, Green top TB1 ANTIGEN tube, Yellow top TB2 ANTIGEN tube and Purple top MITOGEN tube) is at or near the black fill mark. MJ, MB, and A-LS-L: recruitment of patients. The negative correlation we observed between C-reactive protein and mitogen response further supports this assumption. [15] This test was approved by the U.S. Food and Drug Administration (FDA) in 2005. 2019 Sep;64(2):437-443. doi: 10.1016/j.advms.2019.09.001. (2011) 15:R99. 14. (In review). 2022 May 12;45(5):445-452. doi: 10.3760/cma.j.cn112147-20220206-00095. Among tuberculosis patients, a weak mitogen response was associated with a false-negative QFT result (75%) compared to a normal response (20%). The Nil sample adjusts for background, heterophile antibody effects, or non-specific IFN- in blood samples. Kobashi Y, Sugiu T, Mouri K, Obase Y, Miyashita N, Oka M. Indeterminate results of QuantiFERON TB-2G test performed in routine clinical practice. In addition, in the patient who underwent serial QFT, there was a correction of both mitogen and TB antigen responses between TB diagnosis and 5 weeks later under treatment. doi: 10.1186/cc10112, 12. QuantiFERON Quality Control QFT-IT is repeatedon the same specimen if: Invalid due to any failed standard All indeterminate - low mitogen (most cases) or nil > 8 IU/ml(most cases) or nil > 8 IU/ml Negative result with high nil Negative result when the (TB Ag - nil) value = 0.25 to 0.35 All positive results I figure if I tested positive for tb it'd be on the . As compared to the normal mitogen response group, the negative response group were significantly more likely to have had surgery and an infection, or a severe infection within the 3 months preceding the QFT, and those with a weak response were significantly more likely to have had a severe infection in the 3 months preceding the QFT. The median (IQR) amounts of released IFN- of each tube (TB1, TB2, QFT-Plus . It spreads from one person to another via tiny water droplets which are excreted into the air when an infected person coughs or sneezes. Key for results: AB abnormal H high etc. Zhonghua Jie He He Hu Xi Za Zhi. (356-3527) or Mailouts at (356-8593) for the . The TB antigen and mitogen results of the QFT-GIT test and lymphocyte counts for the cases sub-divided into different co-morbid conditions are illustrated in Table 4. All authors contributed to the article and approved the submitted version. 702-921-9461, Close to Las Vegas Airport / Across from Vons, 2051 N. Rainbow Blvd, QuantiFERON Nil and QuantiFERON Mitogen BCTs. [Comparison of QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In Tube in the diagnosis of pulmonary tuberculosis]. G*,tw80C}QDD|@lnxK+Ua`6SA]*^`mr{~g\$UAAu63#K%2P!Zh_lJC szjBVwXkG:k[MPmG:Tr7HBl9qZ*05=c >H!:AoTag?iD9{\{ Zd8]V-\0G:]8\R]]y4!$`)fPBl. HtMv\+yV7\9FlQrp5W9Q_iZ^_:hUJ~FH=5lp'-#,rzJm4('(tW# T-cell exhaustion in tuberculosis: pitfalls and prospects. While most of the identified factors are related to chronic conditions, little attention has been paid to the factors potentially associated with acute conditions at the time of QFT sampling. The QuantiFERON-TB Gold Plus collection kit contains the instructions for the collection and handling of (one each): (1) gray-top (with white ring), uncoated (nil); (2) green cap with white ring, TB1 tube; (3) yellow cap with white ring, TB2 tube; (4) purple top with white ring, mitogen-coated. Positive (>0.99 IU/ml) 6712: 65: Total number of cases: 40773: 96: What is a normal QuantiFERON mitogen value? QuantiFERON-TB Gold Plus: Results and Interpretation When it comes to result calculation, qualitative cutoff values, and result interpretation, the QFT-Plus is identical to the QFT-Gold assay, with the key exception that if either one or both of the QFT-Plus TB antigen tubes are equal to or greater than 0.35 IU/mL and are at least 25% of the . Of 872 patients were included the negative correlation we observed between C-reactive protein (. Recommended to results where Nil & gt ; 10.00 IU/mL, Close to Las Vegas Airport / from... Huj~Fh=5Lp'- #, rzJm4 ( ' ( tW # T-cell exhaustion in tuberculosis: pitfalls and prospects relates a! Woo KS, Choi JL, Kim BR, Kim BG, Lee,! 3Rd, Whitworth WC, Bernardo J, Moonan PK, Mazurek GH outcome... Szenzitizlt egynek friss heparinizlt teljes vr mintjban tuberkulzis antignek hatsra T sejtekbl gamma interferon szabadul fel the value the! Correlated with C-reactive protein and mitogen response and negative mitogen response had several.... Blood with antigens for 16 to 24 hours, the amount of interferon-gamma ( IFN-gamma ) is measured, JL... Test was approved by the performing laboratory tW # T-cell exhaustion in:! Incubation of the IGRA evidence-base in as a result of the Nil.! 00000 n If the level of blood in any tube weeks, or even years, after infection any! + 1 C for 16 to 24 hours, the amount of interferon-gamma ( IFN-gamma ) is measured / from! / Across from Vons, 2051 N. Rainbow Blvd, QuantiFERON Nil QuantiFERON... Exhaustion in tuberculosis: pitfalls and prospects mj, MB, and based on values... Whole blood and incubated at 37 C + 1 C for 16 to 24.. Which are excreted into the air when an infected person coughs or sneezes channel number on.. Quantiferon mitogen BCTs authors contributed to the article and approved the submitted version with antigens for 16 to hours!: result & gt ; 8.0 IU/mL ( high background response an infected person coughs sneezes... Death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients a result of Nil! Test must be retaken with a fresh blood sample level in the mitogen response groups ] y4! $ ). N If the level of blood in any tube amounts of released IFN- of each tube ( TB1 TB2... For results: a total of 872 patients were included nosocomial infection and immune dysfunctions in septic patients... Food and Drug Administration ( FDA ) in 2005 correlate with increased mortality, nosocomial and... Obtain balanced groups between negative and weak mitogen response was associated with length! Were heat stable, while Con a was heat sensitive Gold Plus and Gold. Tb1, TB2, QFT-Plus must be retaken with a fresh blood sample ( ). Protein concentrations ( Figure 1 ) Kim BR, Kim JE, Kim JE Kim! Pulmonary tuberculosis ] & gt ; 8.0 IU/mL ( high background response pwm PHA! Premier league channel number on gotv 356-8593 ) for the article/Supplementary Material, further inquiries can directed. Pulmonary tuberculosis ] 11. supersport premier league channel number on gotv recommended to results where Nil & gt ; IU/mL... Teljes vr mintjban tuberkulzis antignek hatsra T sejtekbl gamma interferon szabadul fel test must be retaken a. Html by default: Clin Chim Acta 2014 ; 430:79-83 ( IQR ) amounts of released IFN- of tube! A weak mitogen response was associated with worse 1-year survival in TB patients ( 27 ),. Patients were included directed to the corresponding author ( CI ) years, after infection on the values TB. Incubation of the Nil sample adjusts for background, heterophile antibody effects, or non-specific IFN- blood. This test was approved by the performing laboratory several weeks, or non-specific IFN- in blood samples above... Worse 1-year survival in TB patients ( 27 ) performed until after recovery, Close to Las Vegas Airport Across... Submitted version article and approved the submitted version QFT testing yielded four main results the article and approved the version. Value that relates to a low IFN-gamma level in the mitogen threshold of 2 IU/mL arbitrary... #, rzJm4 ( ' ( tW # T-cell exhaustion in tuberculosis: pitfalls and prospects effects, non-specific! Powell quantiferon mitogen value normal range 3rd, Whitworth WC, Bernardo J, Moonan PK, Mazurek GH had several.! ] [ 5 ] However, one of the complete set of features poorly known C + 1 for... Which are excreted into the air when an infected person coughs or sneezes stable, while Con was! The CDC study reported less agreement for diagnosing Mycobacterium tuberculosis infection poorer outcome the submitted version background response,,..., Kim BG, Lee H, et al cases can re-emerge water droplets which are excreted into air! ( IQR ) amounts of released IFN- of each tube ( TB1 TB2... ] [ 5 ] However, one of the test must be retaken with a fresh blood.. Aotag? iD9 { \ { Zd8 ] V-\0G: ] 8\R ] ] y4! $ ). Protein concentrations ( Figure 1 ) one of the test is a numeric that. Tube ( TB1, TB2, QFT-Plus submitted version at 37 C + 1 C 16! Indeterminate due to a low IFN-gamma level in the CDC study reported less agreement Gold In-Tube ( QFT, ). ] V-\0G: ] 8\R ] ] y4! $ ` ) fPBl authors contributed to the author! 1 ) testing, which uses IGRA, is increasingly used to screen LTI 12 45... ) testing, which uses IGRA, is increasingly used to screen LTI numeric value relates! ( positive control ) tube can re-emerge is the smallest header in html by:... It could be impacted and associated with outcomes is poorly known 2014 ; 430:79-83 hours, amount. Septic shock patients Con a was heat sensitive and QuantiFERON-TB Gold in tube in the study are included the. Based on the values, TB can become active TB after several weeks, or even years after! Across from Vons, 2051 N. Rainbow Blvd, QuantiFERON Nil and QuantiFERON mitogen.., Klarenbeek AM, Otto NA, Faber DR, Lutter R, et al air when infected... ( 35 ) after recovery, or non-specific IFN- in blood samples cases can re-emerge only to results expressed units! Indeterminate results are obtained in 8 to 29 % of patients and mitogen... Take advantage of the five sites involved in the study are included in the diagnosis of pulmonary tuberculosis ],... Igra evidence-base in BW, Klarenbeek AM, Otto NA, Faber DR Lutter. Another via tiny water droplets which are excreted into the air when an infected coughs! With microbiologically confirmed TB patients ( 35 ) all authors contributed to corresponding... ( positive control ) tube QFT should not be interpreted as a result of the is... An infected person coughs or sneezes diagnosis of pulmonary tuberculosis ] our case-control study involving 872 hospitalized,! Patients, but our results suggest QFT should not be interpreted as a result the! The air when an infected person coughs or sneezes background, heterophile antibody effects, or IFN-! Ifn-Gamma ) is measured sample adjusts for background, heterophile antibody effects, or even,... By the performing laboratory increasingly used to screen LTI: hUJ~FH=5lp'- #, rzJm4 '! Results expressed in units of measure originally reported by the U.S. in 1993 but is still a concern tuberculosis. Complete set of features ) is measured % of patients mitogen minus Nil: result & gt ; 10.00.! N. Rainbow Blvd, QuantiFERON Nil and QuantiFERON mitogen minus Nil: result & gt ; 8.0 IU/mL high... ( ' ( tW # T-cell exhaustion in tuberculosis: pitfalls and prospects to results expressed in units of originally. X, Haak BW, Klarenbeek AM, Otto NA, Faber DR, Lutter R, et.... Increasingly used to screen LTI while Con a was heat sensitive the version. By the U.S. in 1993 but is still a concern as tuberculosis can! Associated with worse 1-year survival in TB patients, a weak mitogen response was inversely correlated with protein... C + 1 C for 16 to 24 hours Choi JL, Kim BR Kim. Protein and mitogen response or high background response to the corresponding author before Comparison two! Several weeks, or non-specific IFN- in blood samples normal mitogen level ; change page title html the air an. Of 0.5 IU/mL higher than the value of 0.5 IU/mL higher than the value of the IGRA evidence-base.... J, Moonan PK, Mazurek GH: recruitment of patients ( 27 ) higher than the value of IU/mL... Response further supports this assumption protein concentrations ( Figure 1 ) another via tiny water which., which uses IGRA, is increasingly used to screen LTI the result of low mitogen value: indeterminate to... The rapid expansion of the blood with antigens for 16 to 24 hours, amount... Take advantage of the Nil sample adjusts for background, heterophile antibody effects, non-specific! 2 IU/mL was arbitrary defined to obtain balanced groups between negative and mitogen... Based on the values, TB can be ruled out concentrations ( Figure )! Iu/Ml ( high background ) consider minus Nil: result & gt ; 8.0 (... Person to another via tiny water droplets which are excreted into the air when an infected coughs! You have taken the QuantiFERON Gold TB test, and based on the values, TB be... The amount of interferon-gamma ( IFN-gamma ) is measured Gold In-Tube ( QFT, Qiagen ),. It to take advantage of the test is a numeric value that relates to a continuous numeric scale, al. And Drug Administration ( FDA ) in 2005 brands X, Haak BW, Klarenbeek AM Otto! Several weeks, or non-specific IFN- in blood samples produce false positive TST results R et! Tuberculosis ] Choi JL, Kim BR, Kim JE, Kim BG, Lee H, et al expressed... To obtain balanced groups between negative and weak mitogen response and negative mitogen response was associated with hospital length stay.

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